Stress perfusion cardiac MRI with regadenoson and gadofoveset trisodium

Initial description of changes in wall motion parameters in normal subjects undergoing rest/regadenoson stress using a tagged MRI sequence

Background Changes in global and regional wall motion between rest and stress are important prognostic markers, uncommonly observed with vasodilator stress radionuclide myocardial perfusion imaging (MPI). Cardiac MRI (CMR) with tagging has the potential to more precisely quantify normal and abnormal ventricular wall motion responses. We herein report CMR findings in 5 very low-likelihood patien...

Cardiovascular effects and tolerance of adenosine versus regadenoson during cardiac MRI perfusion testing

Background Patients referred to cardiac MRI (CMR) for suspicion of obstructive coronary artery disease typically undergo vasodilator stress testing using either adenosine or regadenoson. Both of these agents are effective and have been evaluated for stress testing in both the CMR and nuclear medicine setting but the cardiovascular physiologic effects of each of these agents have not been well s...

Feasibility of detecting myocardial ischemia using first-pass contrast MRI and regadenoson

Background Cardiac stress MR perfusion imaging requires an MRI compatible infusion pump for the administration of adenosine or a non-MRI compatible pump housed in the control room or beyond the 10-Gauss line. Regadenoson is a recently FDA-approved A2A receptor agonist that can be given intravenously in a single bolus. It has been shown to provide diagnostic information regarding myocardial isch...

Regadenoson Cardiac Stress Myocardial Perfusion Scintigraphy

Time resolved measure of coronary sinus flow following regadenoson administration

Objective To use velocity encoded phase contrast MRI to determine timing of peak myocardial blood flow to establish when CMR stress perfusion imaging should be performed after injection of regadenoson.